Histology, tissue morphology and microscopy
Highly-skilled tissue processing, imaging, and analysis
Study design
- Assistance in project planning and experimental set-up based on scientific question
- Evaluation of samples, photodocumentation, and report writing
Histological preparation and techniques
- Undecalcified bone histology with or without implants (eg, metal, calcium phosphates, polymers)
- Sectioning of resin embedded samples with specialty equipment
- Contact radiography
- Decalcification of tissues
- Paraffin embedding and sectioning
- Cryosectioning
- Immunohistochemistry (with protocol planning)
- Routine to special stains (for resin and non-resin embedded samples)
Microscopy and image analysis
- Brightfield light microscopy for sections with or without implants
- Epifluorescent microscopy for fluorochrome labelled sections (eg, bone labels, marked antibodies)
- Macrophotography for overview images of larger samples
- Confocal laser microscopy for optical sectioning
- Scanning electron microscope equipped with Energy Dispersive X-Ray Spectroscopy (EDX or EDS)
- White light profilometry for surface characterization (eg, roughness values)
- Quantitative analysis (eg, lengths, areas, numbers) on histological samples
![](/-/media/project/aocd/aof/what-we-do/research-innovation/cro-services-and-resources/histology-tissue-morphology-and-microscopy/ari_promo_services_4histo_2_900x506.png?h=506&iar=0&w=900&hash=1077A342983928BEE3936A1809910CEA)
CD31 immunohistochemical stain showing a blood vessel, of a decalcified, cryosectioned coracoclavicular ligament
![](/-/media/project/aocd/aof/what-we-do/research-innovation/cro-services-and-resources/histology-tissue-morphology-and-microscopy/ari_promo_services_4histo_1_900x506.png?h=506&iar=0&w=900&hash=FAC9FB111886D21997BD68930B8D7C32)
Safranin O/Fast Green staining: resin embedded sheep lumbar disc
Qualifications
- Certified vet. pathologist
Certification
- ISO 9001
- Good Laboratory Practice (GLP)
Contact
![](/-/media/project/aocd/aof/what-we-do/research-innovation/cro-services-and-resources/aof_ari_portrait_staff_bentz_ulrich_600x600.jpg?h=180&iar=0&w=180&hash=1E04D4E7253B24740DC4D339CBB20C6B)
Ulrich Bentz
AO Research Institute Davos
Clavadelerstrasse 8
7270 Davos Platz
Switzerland
Tel.: +41 81 414 23 26